Bovine viral diarrhea virus type 2 (BVDV-2)

Bovine viral diarrhea virus type 2 (BVDV-2, also known as *Pestivirus tauri*) is a positive-sense, single-stranded RNA virus belonging to the genus *Pestivirus* within the family *Flaviviridae*.[2][4] The virus infects cattle and causes bovine viral diarrhea, with BVDV-2 generally considered more virulent than type 1, often associated with severe acute disease including hemorrhagic manifestations.[5][6] BVDV-2 exists in cytopathic and non-cytopathic biotypes; non-cytopathic strains predominate in field infections and can establish persistent infection in immunotolerant animals.[4] The virus enters cells through E1/E2 envelope glycoprotein-mediated mechanisms, with E2 serving as a critical determinant of cellular tropism and containing major neutralizing antibody epitopes.[1] While BVDV-2 itself is not a conventional drug target, its envelope proteins (particularly E1 and E2) represent potential targets for neutralizing antibodies and vaccine development strategies for disease control and prevention.

Other names

BVDV type 2Pestivirus tauriPestivirus BBovine pestivirus type 2