BPI fold-containing family C protein (BPIFC)

BPI fold-containing family C protein (BPIFC) is a member of the BPI/LBP/PLUNC superfamily of lipid-binding serum glycoproteins, defined structurally by the presence of a conserved BPI fold, which consists of two domains forming a boomerang-shaped molecule with binding sites able to interact with hydrophobic ligands such as bacterial lipopolysaccharide. While closely related family members are established as components of host defense (such as bactericidal/permeability-increasing protein and PLUNC proteins), the specific biological function and disease relevance of BPIFC remain incompletely elucidated. There is no current evidence to support BPIFC as a direct therapeutic target, clinical biomarker, or molecule with established small-molecule interactions. It is primarily annotated as a protein-coding gene implicated by sequence similarity in lipid binding, potentially relevant to the innate immune response, but its role in human health or disease has yet to be clearly defined.

Other names

BPIFCBPIL2BPI-like 2dJ149A16.7Bactericidal/permeability-increasing protein-like 2BPI fold-containing family C protein