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Target intelligence / Profile preview
Brachyury transcription factor (TBXT)
- Target
- TBXT
- Molecular classification
- Transcription factor, T-box transcription factor
01
Overview
Brachyury (TBXT) is a transcription factor essential for notochord and posterior mesoderm formation during embryonic development. It is a key biomarker for chordoma, a rare cancer derived from notochordal remnants, and is implicated in epithelial-to-mesenchymal transition and tumor metastasis in other cancers. It is considered a lineage-survival oncogene in chordoma and a potential therapeutic target.
- Other names
- TBrachyury
02
Mechanism of action
Directly regulates gene expression by binding to DNA; induces or represses transcription of target genes.
03
Biological functions
Notochord formationPosterior mesoderm formationTail formationAxial developmentTranscriptional regulation
04
Disease associations
ChordomaCancerEpithelial-to-mesenchymal transition (EMT)Tumor metastasis
05
Safety considerations
Potential for off-target effects due to widespread expression during embryonic developmentChallenges in targeting transcription factors with small molecules due to complex structureInducing developmental defects if targeted during pregnancy
06
Biomarkers
Chordoma diagnosisEMT marker in cancerPredictive biomarker in chordoma and other cancers
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