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Target intelligence / Profile preview
Bradykinin B₂ receptor (B2R)
- Target
- B2R
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The Bradykinin B₂ receptor is a G-protein coupled receptor that mediates the effects of bradykinin, a peptide involved in inflammatory pain and other physiological processes. Activation of the B₂ receptor increases the excitability of sensory neurons, contributing to pain perception. It is ubiquitously expressed and represents a potential therapeutic target for pain management and inflammatory conditions.
- Other names
- Bradykinin receptor B2BDKRB2 receptor
02
Mechanism of action
Gq and Gi protein activation, leading to increased intracellular calcium levels and inhibition of adenylate cyclase. Activation of mitogen-activated protein kinase (MAPK) pathways.
03
Biological functions
Signal transductionPain perceptionInflammationRegulation of vascular permeability
04
Disease associations
PainInflammationInflammatory disordersNeurodegenerative diseaseCardiovascular disease
05
Interacting drugs
Bradykinin
2 more in the full profile.
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