Target intelligence / Profile preview

Bradykinin B1 receptor (None)

Target: None
Molecular classification: G protein-coupled receptor, Receptor

Overview

The Bradykinin B1 receptor (B1R) is a G protein-coupled receptor that is typically absent under normal physiological conditions but is highly inducible following tissue injury or in inflammatory states. Its activation by kinins like desArg^9-bradykinin mediates inflammatory responses, pain, and cardiovascular effects. It is a target for potential treatment strategies for inflammatory disorders and cardiovascular diseases.

Mechanism of action

Agonists bind to B1 receptor leading to increased cytosolic calcium ion concentration, initiating inflammatory responses. Antagonists block this binding and reduce inflammation and pain.

Biological functions

Signal transductionInflammatory response mediationCell migrationBlood pressure regulationPain perception

Disease associations

InflammationCardiovascular diseaseChronic pain syndromesVascular damageAtherosclerosis

Safety considerations

Potential for off-target effects due to GPCR signaling complexity.Concerns related to blood pressure dysregulation.

Interacting drugs

desArg^9-bradykinin

2 more in the full profile.

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