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Target intelligence / Profile preview
Bradykinin B2 Receptor (BDKRB2)
- Target
- BDKRB2
- Molecular classification
- G protein-coupled receptor, GPCR, Class A (rhodopsin-like) GPCR
01
Overview
The Bradykinin B2 receptor (BDKRB2) is a G-protein coupled receptor that plays crucial roles in inflammatory processes, pain signaling, and vascular function. Activation of the receptor by bradykinin and kallidin leads to downstream signaling through multiple G protein families, ultimately resulting in increased intracellular calcium, MAPK activation, and other cellular responses. The receptor is ubiquitously expressed and is implicated in several clinical conditions, including osteoarthritis, blood pressure regulation, and respiratory diseases, making it a potential therapeutic target for various inflammatory and pain-related conditions.
- Other names
- B2 receptorBK2 receptor
02
Mechanism of action
G protein activation (Gq/G11, Gi/Go, Gs), calcium mobilization, MAPK pathway activation, β-arrestin recruitment
03
Biological functions
Signal transductionVasodilationInflammationPain signalingSmooth muscle contraction
04
Disease associations
InflammationPainCardiovascular diseaseRespiratory diseaseOsteoarthritis
05
Interacting drugs
Bradykinin
5 more in the full profile.
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