Bradykinin Degradation Pathway

The bradykinin degradation pathway is the process by which the nonapeptide bradykinin is broken down into inactive fragments, primarily by enzymes such as ACE, carboxypeptidase N, aminopeptidase P and neprilysin. This rapid degradation is crucial for controlling bradykinin's potent effects on vasodilation, vascular permeability, and pain. Inhibition of these enzymes, particularly ACE, can lead to elevated bradykinin levels and potential adverse effects like angioedema, while also providing therapeutic benefits in certain cardiovascular conditions.

Other names

Bradykinin metabolismKinin degradationBradykinin inactivation

Inhibition of bradykinin-degrading enzymes leads to increased bradykinin levels.