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Bradykinin Metabolism (None)

Target: None
Molecular classification: Metabolic Pathway

Overview

Bradykinin metabolism is the process by which bradykinin, a potent vasoactive peptide, is synthesized and degraded. Bradykinin is generated from high-molecular-weight kininogen by kallikrein or plasmin. Its short half-life is due to rapid degradation by several enzymes, including angiotensin-converting enzyme (ACE), aminopeptidase P, carboxypeptidases N/M, and neprilysin. ACE is the primary enzyme responsible for bradykinin inactivation. Inhibiting bradykinin metabolism can lead to increased bradykinin levels, potentially causing adverse effects such as angioedema.

Mechanism of action

N/A

Biological functions

Regulation of blood pressureInflammationPain mediationVascular permeability

Disease associations

AngioedemaInflammationCardiovascular disease

Safety considerations

Angioedema (due to ACE inhibitor or neprilysin inhibitor use)

Interacting drugs

ACE inhibitors

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