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Target intelligence / Profile preview
Bradykinin Receptor (BRKR)
- Target
- BRKR
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The bradykinin receptor family comprises G-protein coupled receptors (GPCRs) that mediate the biological effects of bradykinin. The two main subtypes are the Bradykinin receptor B1 (B1R) and Bradykinin receptor B2 (B2R). These receptors play key roles in inflammation, pain, and cardiovascular regulation. B2R is constitutively expressed and mediates normal physiological responses, while B1R is inducible upon tissue injury or inflammation and contributes to chronic pain and inflammation.
- Other names
- Bradykinin receptorsKinin receptors
02
Mechanism of action
Activation of G proteins (Gq, Gi) leading to downstream signaling cascades, including phospholipase C activation and increased intracellular calcium, and inhibition of adenylate cyclase.
03
Biological functions
Signal transductionVasodilationIncreased vascular permeabilityPain signalingInflammation
04
Disease associations
Hereditary angioedemaInflammationChronic painCardiovascular disease
05
Safety considerations
ACE inhibitor-induced cough and angioedemaDysregulation can contribute to hereditary angioedema.
06
Interacting drugs
Icatibant
2 more in the full profile.
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