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Bradykinin Receptor B1 (None)

Target: None
Molecular classification: G protein-coupled receptor, Receptor

Overview

Bradykinin receptor B1 (B1R) is a G protein-coupled receptor (GPCR) that is induced primarily under pathological conditions, such as inflammation and tissue injury. It mediates inflammatory responses, cell migration, and contributes to chronic pain. Its activation increases cytosolic calcium ion concentration. It is a target for research into chronic pain management and anti-inflammatory therapies.

Mechanism of action

Agonist or antagonist binding to BDKRB1 to modulate downstream signaling pathways, primarily calcium signaling and inflammatory cascades.

Biological functions

Signal transductionInflammatory responseCell migrationRegulation of blood pressureCalcium signalingLeukocyte migration

Disease associations

InflammationChronic painCancer

Safety considerations

Potential for off-target effects due to the role of bradykinin signaling in various physiological processes.Possible involvement in tumor progression.

Interacting drugs

bradykinin(1-8)

1 more in the full profile.

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