BRAF-activated non-protein coding RNA (BANCR)

BRAF-activated non-protein coding RNA (BANCR, also known as LINC00586) is a long non-coding RNA initially identified as induced by BRAF^V600E^ mutation, particularly in melanoma[5]. It is 693 nucleotides in length and located on chromosome 9[1]. BANCR is overexpressed in multiple cancers, including colorectal, melanoma, and cervical carcinomas. Mechanistically, BANCR functions primarily as an oncogenic lncRNA, promoting tumor cell proliferation, migration, invasion, epithelial-to-mesenchymal transition (EMT), and generally facilitating tumor progression. In colorectal cancer, BANCR recruits the histone demethylase LSD1 to the ASXL1 gene promoter, leading to epigenetic silencing of the tumor suppressor ASXL1 through H3K4me2 demethylation, thereby promoting oncogenic processes. In cervical cancer, BANCR modulates proliferation and apoptosis in part by regulating the expression of CREB1, via antagonism of miR-582-5p[1][4]. High BANCR expression is associated with poor prognosis and aggressive disease, and its knockdown suppresses tumorigenic properties in experimental models[1][2][4][5][3]. It is under investigation as a potential biomarker and therapeutic target, but no approved or clinically established BANCR-targeting drugs exist at this time.

Other names

LINC00586BANCRBRAF-activated lncRNA

Regulation of gene expression via epigenetic silencing; recruits LSD1 to the ASXL1 promoter, leading to H3K4me2 demethylation and transcriptional repression of ASXL1; may regulate CREB1 via miR-582-5p in some cancers[1][4].