BRAF pseudogene 1 (BRAFP1)

BRAF pseudogene 1 (BRAFP1) is a non-coding pseudogene located on chromosome X that shares high sequence homology with the functional BRAF gene, which encodes a serine/threonine kinase involved in MAPK signaling. Although BRAFP1 does not encode a functional protein, it acts at the RNA level as a competitive endogenous RNA (ceRNA), functioning as a miRNA decoy for several microRNAs, such as miR-30a, miR-182, miR-590, and miR-876. Through this mechanism, BRAFP1 upregulates BRAF expression and enhances MAPK pathway signaling, which promotes tumorigenesis—particularly in lymphoma models. Although aberrant upregulation or genomic gain of BRAFP1 is linked with increased cancer risk, BRAFP1 itself is not a druggable molecular target or conventional therapeutic target like receptors, enzymes, or transporters. Its primary significance is as a molecular regulator via RNA–RNA interactions, situating it in the broader context of pseudogene-mediated post-transcriptional regulation[1][2][3][4][5]. Summary of correctness: BRAFP1 is not a conventional drug target, nor does it encode a protein or receptor; its biological significance derives from RNA-based modulation of gene expression. It should not be classified as a receptor, enzyme, or transporter, nor is it currently a direct target for any approved drug therapies.

Other names

BRAF2BRAFPS2V-Raf murine sarcoma viral oncogene homolog B pseudogene 1V-Raf murine sarcoma viral oncogene homolog B pseudogene 2V-Raf murine sarcoma viral oncogene homolog B1 pseudogene 1V-Raf murine sarcoma viral oncogene homolog B1 pseudogene 2Murine sarcoma viral (V-Raf) oncogene homolog B1 oncogene