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Target intelligence / Profile preview
B-Raf V600E (BRAF V600E)
- Target
- BRAF V600E
- Molecular classification
- Serine/threonine kinase, Enzyme, Kinase, MAPK pathway component
01
Overview
B-Raf V600E refers to a specific mutation in the BRAF gene, where the amino acid valine (V) at position 600 is replaced by glutamic acid (E). This single-point mutation results in a constitutively active form of the B-Raf protein, a serine/threonine kinase involved in cell signaling pathways that regulate cell growth and division. The mutant protein can signal independently of upstream Ras activation, leading to continuous MAPK pathway activity, driving uncontrolled cellular proliferation and survival. It is a therapeutic target in multiple cancer types and can be detected through DNA sequencing and immunohistochemistry.
- Other names
- BRAF V600E mutantV600E B-RafB-Raf V600E kinase
02
Mechanism of action
Inhibition of mutated B-Raf kinase activity.
03
Biological functions
Signal transductionCell proliferationCell growthMAPK signaling pathway regulation
04
Disease associations
CancerMelanomaColorectal cancerPapillary thyroid carcinomaHairy cell leukemiaLangerhans cell histiocytosis
05
Safety considerations
Resistance developmentOff-target effectsSecondary malignancies
06
Interacting drugs
Dabrafenib
2 more in the full profile.
07
Biomarkers
BRAF V600E mutation status
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