Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
BRAF V600E Kinase (BRAF(V600E))
- Target
- BRAF(V600E)
- Molecular classification
- Protein Kinase, Serine/threonine-protein kinase, Enzyme
01
Overview
BRAF(V600E) kinase is a mutant form of the B-Raf protein, a serine/threonine-specific protein kinase. The V600E mutation results in constitutive activation of the kinase, leading to continuous downstream signaling through the MAPK/ERK pathway, promoting uncontrolled cell proliferation and survival. It is a significant oncogenic driver and therapeutic target in several cancers, including melanoma, colorectal cancer, and thyroid carcinoma.
- Other names
- BRAF(V600E) mutantV600E BRAFBRAFV600E
02
Mechanism of action
Inhibition of BRAF(V600E) kinase activity, leading to decreased MAPK/ERK pathway signaling.
03
Biological functions
Signal transductionCell proliferationCell survivalMAPK/ERK pathway activation
04
Disease associations
CancerMelanomaColorectal cancerThyroid carcinomaHairy cell leukemia
05
Safety considerations
Resistance developmentParadoxical activation of MAPK pathway in BRAF wild-type cells
06
Interacting drugs
PLX4720
3 more in the full profile.
07
Biomarkers
BRAF(V600E) mutation status
Beyond the preview
Go deeper on BRAF V600E Kinase (BRAF(V600E)).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BRAF V600E Kinase (BRAF(V600E)).