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Brain-derived Neurotrophic Factor (None)
- Target
- None
- Molecular classification
- Neurotrophin, Growth Factor, Signaling Protein
01
Overview
Brain-derived neurotrophic factor (BDNF) is a protein that supports the survival, growth, and differentiation of neurons. It plays a critical role in learning, memory, and synaptic plasticity. Decreased levels of BDNF are linked to neurodegenerative and psychiatric disorders.
- Other names
- BDNF
02
Mechanism of action
Binds to TrkB and p75NTR receptors, activating intracellular signaling cascades that promote neuronal growth/survival/synaptic plasticity or apoptosis depending on the receptor and context.
03
Biological functions
Neuronal differentiationNeuronal maturationNeuronal survivalSynaptic plasticityLong-term memory formationLearning processesRegulation of synaptic transmissionEnergy metabolism regulationNeurogenesis
04
Disease associations
Neurodegenerative diseasesParkinson's diseaseAlzheimer's diseaseHuntington's diseaseMultiple sclerosisDepressionGlioblastoma
05
Safety considerations
Altered signaling implicated in certain cancersKnockout studies show severe developmental defects
06
Interacting drugs
Antidepressants
07
Biomarkers
BDNF levels in blood or saliva
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