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Target intelligence / Profile preview
Brain-Derived Neurotrophic Factor Receptor (BDNF receptor)
- Target
- BDNF receptor
- Molecular classification
- Receptor Tyrosine Kinase (TrkB), Tumor Necrosis Factor Receptor Superfamily (p75NTR)
01
Overview
The brain-derived neurotrophic factor receptor refers to the cell surface receptors that bind and mediate the effects of brain-derived neurotrophic factor (BDNF). The two main receptors are TrkB, a high-affinity tyrosine kinase receptor, and p75NTR/LNGFR, a low-affinity pan-neurotrophin receptor. TrkB activation promotes neuronal survival, differentiation, and synaptic plasticity, while p75NTR can induce apoptosis or neurite outgrowth depending on the cellular context. Dysregulation of these receptors is implicated in neurological diseases.
- Other names
- TrkBTropomyosin receptor kinase BNTRK2p75NTRLNGFRLow-affinity nerve growth factor receptorp75 neurotrophin receptor
02
Mechanism of action
Mature BDNF binds to TrkB, activating intracellular signaling cascades (PI3K/Akt, MAPK/ERK, PLCγ) promoting neuronal survival and plasticity. ProBDNF and mature BDNF can bind to p75NTR, triggering apoptosis or neurite outgrowth depending on cellular context and co-receptors.
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityMemory formationNeurotransmission regulationApoptosis (p75NTR)Neurite outgrowth (p75NTR)
04
Disease associations
DepressionAlzheimer's diseaseParkinson's diseaseNeurological disorders
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