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Target intelligence / Profile preview
Brain-derived Neurotrophic Factor Receptor TrkB (NTRK2)
- Target
- NTRK2
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
NTRK2, also known as TrkB (Tropomyosin receptor kinase B), is a membrane-bound receptor tyrosine kinase primarily involved in the development and function of the nervous system. It is activated by neurotrophins such as BDNF, NT-4, and NT-3, triggering downstream signaling cascades that promote neuronal survival, differentiation, synaptic plasticity, and axon/dendrite growth. Dysregulation of NTRK2 has been linked to obesity, mood disorders, and neurological diseases.
- Other names
- TrkBTropomyosin receptor kinase B
02
Mechanism of action
Ligand binding induces receptor dimerization and autophosphorylation, activating downstream signaling pathways (Ras-MAPK/ERK, PI3K-Akt, PLCγ).
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityAxon/dendrite growthCell proliferationSignal transduction
04
Disease associations
ObesityMood disordersDepressionNeurological diseasesNeurodevelopmental conditions
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