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Target intelligence / Profile preview
Brain-expressed protein associating with Nedd4 homolog (BEAN1)
- Target
- BEAN1
- Molecular classification
- Protein, Membrane protein
01
Overview
The BEAN1 gene encodes a protein associated with NEDD4, a ubiquitin-protein ligase. It is implicated in spinocerebellar ataxia type 31 and has been linked to poor prognosis and treatment resistance in cancer, particularly through its role in extracellular matrix remodeling and signaling pathways like Wnt and TGF-β[1][4][5].
- Other names
- BEANBrain-expressed protein associating with Nedd4 homologProtein BEAN1SCA31
02
Mechanism of action
Not well-defined for drugs targeting BEAN1, but it may involve modulation of signaling pathways like Wnt/β-catenin and TGF-β.
03
Biological functions
Signal transductionProtein-protein interactionCell proliferationImmune response modulation
04
Disease associations
Spinocerebellar ataxia type 31Cancer (specifically, poor prognosis and resistance to chemotherapy in rectal adenocarcinoma)
05
Safety considerations
The safety concerns are more related to its association with disease progression (e.g., resistance to chemotherapy) rather than direct drug safety.
06
Biomarkers
May serve as a biomarker for prognosis in certain cancers, like rectal adenocarcinoma.
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