Brain metabolism modulation

Brain metabolism modulation refers to the therapeutic manipulation of energy-producing processes within the central nervous system to address bioenergetic deficits associated with neurological and metabolic disorders [1, 2]. It is not a discrete molecular target, such as a single receptor or enzyme, but a broad physiological strategy targeting pathways related to glucose transport, mitochondrial function, and alternative fuel utilization [2, 4]. Chronic impairment in brain glucose uptake and mitochondrial efficiency is a hallmark of neurodegenerative diseases like Alzheimer's and Parkinson's, where metabolic decline often precedes clinical symptoms [1, 4]. Therapeutic approaches to modulate brain metabolism include pharmacological agents like GLP-1 receptor agonists and SGLT2 inhibitors, which improve insulin sensitivity and glucose utilization [4]. Additionally, non-pharmacological methods such as deep brain stimulation (DBS) and ketogenic diets are explored to bypass glucose processing defects or stimulate regional metabolic activity [7, 10, 11]. By restoring metabolic homeostasis, these strategies aim to enhance neuroplasticity, reduce neuroinflammation, and preserve cognitive and motor functions in affected patients [5, 6, 11].

Other names

Brain energy metabolism regulationCerebral metabolic modulationCerebral bioenergetic enhancementBrain metabolic rescue

Restoration of cerebral energy homeostasis through the enhancement of glucose uptake, improvement of mitochondrial efficiency, and utilization of alternative fuel sources such as ketone bodies [1, 2, 4].