Brain mitochondrial carrier protein 1 (SLC25A14)

Brain mitochondrial carrier protein 1 (SLC25A14, also known as UCP5 or BMCP1) is a mitochondrial inner membrane transporter belonging to the solute carrier 25 (SLC25) family, specifically the mitochondrial uncoupling protein (UCP) group. SLC25A14 is primarily expressed in the brain but also present in testis and pituitary. Its main functions include mediating the mitochondrial proton leak (uncoupling oxidative phosphorylation from ATP synthesis) and facilitating the transport of various inorganic anions (such as sulfate, sulfite, thiosulfate, and phosphate) and amino acids (notably aspartate and glutamate) across the inner mitochondrial membrane. Through these activities, SLC25A14 modulates mitochondrial membrane potential, mitigates oxidative stress, regulates mitochondrial efficiency and apoptosis, and provides neuroprotection under oxidative or metabolic stress conditions. SLC25A14 has been implicated in neurodegenerative diseases and aging, as well as broader metabolic and mitochondrial disorders. There are currently no clinically approved drugs known to directly target SLC25A14.

Other names

Brain mitochondrial carrier protein 1SLC25A14BMCP1UCP5UNQ791/PRO1682BMCP-1mitochondrial uncoupling protein 5brain mitochondrial carrier protein 1solute carrier family 25 member 14

Uncoupling of oxidative phosphorylation from ATP synthesis by facilitating proton and anion transport across the mitochondrial inner membrane, reduction of mitochondrial membrane potential, modulation of oxidative and metabolic stress responses