Brain network connectivity

Brain network connectivity refers to the structural and functional interconnections among neurons and brain regions that enable information processing, communication, and higher-order brain functions such as cognition and behavior. It encompasses anatomical pathways like white matter tracts and functional correlations observed in imaging techniques including fMRI for co-activation patterns and diffusion MRI for structural links. This connectivity forms complex networks characterized by small-world topology, modular organization, and hub regions that integrate segregated functions across the brain. Disruptions in these networks are implicated in neurodegenerative diseases like Alzheimer's and Parkinson's, where altered connectivity patterns precede overt pathology and may facilitate protein spreading. In schizophrenia, connectivity differences aid classification and reveal dysfunctional integration. While not a single molecular entity like a receptor or enzyme, brain network connectivity is studied via connectomics to map every neuron and synapse, providing insights into how wiring defines neural function and self-identity. Approaches like molecular connectivity using PET tracers reveal neurotransmitter-specific network changes, complementing traditional methods.

Other names

connectomeneural connectivityfunctional connectivitystructural connectivitymolecular connectivity