Target intelligence / Profile preview

Brain Network Modulation

Molecular classification
Systems-level process, Functional target
01

Overview

Brain network modulation refers to the process of influencing or altering the activity and connectivity of neural networks within the brain. This can be achieved through various means, including non-invasive brain stimulation techniques, pharmacological agents (neuromodulators), or computational interventions. The goal is often to evoke, enhance, diminish, or reshape ongoing brain activity for scientific investigation or therapeutic purposes. It targets large-scale neural circuits rather than single molecules or receptors, and involves changing how groups of neurons communicate and synchronize their activity across different regions. Techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are commonly used, as well as neuromodulators like dopamine, serotonin, and acetylcholine.

02

Mechanism of action

Modulation of network activity via non-invasive stimulation or neuromodulatory action on GPCRs.

03

Biological functions

Alters activity/connectivity among distributed neural populationsNeuroplasticityRegulation of neural circuitsSynchronization of neural activity
04

Disease associations

Neurological disordersNeuropsychiatric disordersAlzheimer's disease
05

Safety considerations

Seizures (TMS)Skin irritation (tDCS)HeadachesCognitive side effectsPotential for unintended network changes
06

Interacting drugs

Dopamine agonists/antagonists

4 more in the full profile.

07

Biomarkers

Functional connectivitySynchronization patternsCortical excitabilityNetwork topology

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