Brain specific DNA-damage related long non-coding RNA 1 (MIR9-3HG)

MIR9-3 host gene encodes a long non-coding RNA (lncRNA), frequently referred to as Brain Specific DNA-damage Related lncRNA 1 (BS-DRL1) and LINC00925, which is highly expressed in brain tissue and certain cancers. MIR9-3HG regulates the DNA damage response and genome stability in neurons by interacting with HMGB1, and modulates cancer cell proliferation, migration, invasion, apoptosis, and EMT through sponging specific microRNAs (miR-138-5p in lung squamous cell carcinoma, miR-498 in cervical cancer), thereby influencing downstream mRNA targets such as LIMK1 and EP300. Overexpression is associated with aggressive cancer phenotypes and poor prognosis; in neurons, it has a protective role in response to genotoxic stress and may modulate neurodegenerative processes. MIR9-3HG functions independently from the intronic microRNA (miR-9-3) it hosts, highlighting its distinct regulatory actions beyond the miRNA. No approved drugs directly target this lncRNA, and its therapeutic relevance remains in early-stage research. Expression levels may serve as biomarkers in cancer diagnosis and prognosis.

Other names

MIR9-3 host geneBS-DRL1lnc-FANCI-2LINC00925CTD-2335A18.1long intergenic non-protein coding RNA 925

Potential mechanisms include gene knockdown, antisense targeting, or CRISPR-mediated silencing; lncRNA–miRNA–mRNA regulatory axis.