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Branched-chain amino acid biosynthesis pathway (BCAA biosynthesis pathway)
- Target
- BCAA biosynthesis pathway
- Molecular classification
- Enzymatic pathway, Metabolic pathway
01
Overview
The branched-chain amino acid biosynthesis pathway is crucial for the synthesis of valine, leucine, and isoleucine, which are essential for protein synthesis in bacteria and plants. This pathway involves eight enzymes and plays a vital role in bacterial growth and survival, making it a potential target for antimicrobial drugs and herbicides. Dysfunction in this pathway can lead to metabolic disorders in humans, such as maple syrup urine disease.
- Other names
- Branched-chain amino acid synthesisBCAA pathwayValine, leucine, and isoleucine biosynthesis
02
Mechanism of action
Inhibition of key enzymes in the BCAA biosynthesis pathway (e.g., acetolactate synthase) to disrupt bacterial growth or plant metabolism.
03
Biological functions
Amino acid synthesisProtein synthesisMaintenance of internal pHAdaptation to environmental conditions (e.g., growth in milk for *Streptococcus thermophilus*)
04
Disease associations
Infection (e.g., targets for antimicrobial drugs)Metabolic disorders (e.g., maple syrup urine disease if the pathway is dysfunctional)
05
Safety considerations
Overcumulation of BCAAs or their precursors can lead to metabolic issues.
06
Interacting drugs
Herbicides (e.g., those targeting enzymes in the pathway like acetolactate synthase)
1 more in the full profile.
07
Biomarkers
Levels of BCAAs or their precursors might be used as biomarkers in metabolic disorders.
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