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Target intelligence / Profile preview
Break repair meiotic recombinase recruitment factor 1 (BRME1)
- Target
- BRME1
- Molecular classification
- Other, DNA repair factor, Protein coding gene
01
Overview
Break repair meiotic recombinase recruitment factor 1 (BRME1) is a protein coding gene essential for meiotic double-strand break repair. It plays a central role in homologous recombination during meiosis, specifically by modulating the localization and stabilization of recombinases (DMC1:RAD51) to meiotic double-strand break (DSB) sites through interactions with and stabilization of the BRCA2:HSF2BP complex. This function is critical for homologous synapsis, crossover formation, and progression of spermatogenesis, thereby affecting male fertility. Loss or dysfunction of BRME1 is associated with impaired meiotic DSB repair, leading to developmental disorders and infertility. BRME1 does not currently have a known therapeutic targeting profile or any approved interacting drugs[1][3][7][11].
- Other names
- C19orf574930432K21RikMamerrMeiok21
02
Biological functions
Double-strand break repair involved in meiotic recombinationSpermatogenesisDamaged DNA bindingMeiotic progressionProtein localization to site of double-strand break
03
Disease associations
Intellectual developmental disorder (autosomal recessive 3)AutismMale infertility
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