Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Breakpoint Cluster Region-Abelson Murine Leukemia Viral Oncogene Homolog Fusion Protein
- Molecular classification
- Fusion Protein, Tyrosine Kinase
01
Overview
BCR-ABL is a fusion protein with constitutive tyrosine kinase activity, resulting from the translocation between chromosomes 9 and 22, known as the Philadelphia chromosome. This fusion gene is a hallmark of chronic myelogenous leukemia (CML) and some other leukemias. BCR-ABL has constitutive tyrosine kinase activity, which leads to uncontrolled cell proliferation. It phosphorylates itself and numerous downstream signaling proteins, disrupting normal cellular processes such as apoptosis, differentiation, and adhesion—driving leukemogenesis.
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationTyrosine kinase signalingRegulation of apoptosisSignal transduction
04
Disease associations
CancerChronic Myelogenous Leukemia (CML)Acute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia
05
Safety considerations
Drug resistance due to mutationsOff-target effects of tyrosine kinase inhibitors
06
Interacting drugs
4 more in the full profile.
07
Biomarkers
BCR-ABL transcript levelsBCR-ABL protein levelsBCR-ABL kinase domain mutations (e.g., T315I)
Beyond the preview
Go deeper on Breakpoint Cluster Region-Abelson Murine Leukemia Viral Oncogene Homolog Fusion Protein.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Breakpoint Cluster Region-Abelson Murine Leukemia Viral Oncogene Homolog Fusion Protein.