Breakpoint cluster region protein (BCR)

The **breakpoint cluster region protein** (BCR) is a multidomain enzyme with serine/threonine kinase activity, GTPase-activating protein (GAP) activity, and guanine nucleotide exchange factor (GEF) activity for the Rho family of GTPases, including Rac1 and RhoA[1][2][3][8]. BCR plays important roles in cellular signaling pathways that regulate cytoskeletal organization and cell migration. Clinical significance arises predominantly from chromosomal translocation t(9;22) leading to the BCR-ABL1 fusion gene, which encodes a constitutively active tyrosine kinase and is the hallmark of chronic myeloid leukemia and some acute leukemias. BCR itself participates in various signaling interactions, but it is as the BCR-ABL1 fusion oncoprotein that it is targeted therapeutically[1][2][3][8].

Other names

BCR activator of RhoGEF and GTPaserenal carcinoma antigen NY-REN-26BCR1D22S11D22S662CMLPHLALLbreakpoint cluster region protein isoform 1breakpoint cluster region protein isoform 2

Tyrosine kinase inhibition (by targeting the abnormal BCR-ABL1 fusion protein activity, which drives unregulated cell growth)