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Target intelligence / Profile preview
Breast carcinoma amplified sequence 3 (BCAS3)
- Target
- BCAS3
- Molecular classification
- Other (Cytoskeletal protein, Microtubule-associated protein)
01
Overview
Breast carcinoma amplified sequence 3 (BCAS3) is a cytoskeletal protein highly expressed in breast cancer, where its gene is frequently amplified and overexpressed. It regulates angiogenesis and mediates endothelial cell migration and polarity, at least in part by modulating Cdc42 activation and interacting with microtubules. BCAS3 is also a transcriptional coactivator of estrogen receptor alpha (ER-α) and is involved in histone acetylation, supporting a role in both cell migration and gene regulation. Its overexpression is mainly linked to hormone-responsive and angiogenic tumors, and it is implicated in a positive feedback loop that amplifies ER-α signaling in breast malignancies.
- Other names
- BCAS3 microtubule associated cell migration factorFLJ20128PHAF2GAOB1Rudhiraphagophore assembly factor 2HEMARSMAABBCAS3/BCAS4 fusionbreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
02
Biological functions
AngiogenesisCell migrationRegulation of cell polarityRegulation of cytoskeletonHistone acetyltransferase activityTranscription coactivator activity
03
Disease associations
Cancer (notably breast cancer)NeoplasmAngiogenic disorders
04
Biomarkers
Amplification/overexpression in breast cancer
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