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Target intelligence / Profile preview
Brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1)
- Target
- GBF1
- Molecular classification
- Guanine nucleotide exchange factor, GEF
01
Overview
GBF1 is a guanine nucleotide exchange factor (GEF) primarily for ADP-ribosylation factors (ARFs), which are small GTPases involved in vesicular trafficking. GBF1 is essential for maintaining Golgi architecture, facilitating secretion, and regulating the recruitment of proteins to membranes by mediating GDP-to-GTP exchange on ARFs. It plays roles in intracellular transport, Golgi apparatus maintenance, mitochondrial organization, viral replication, and host-pathogen interactions. Inhibitors like Brefeldin A and Golgicide A block its GEF activity by preventing GDP/GTP exchange on ARFs.
02
Mechanism of action
Inhibition of GDP-GTP exchange on ARFs
03
Biological functions
Vesicular traffickingProtein recruitment to membranesRegulation of Golgi apparatus structure and dynamicsADP-ribosylation factor (ARF) activation
04
Disease associations
Viral replicationNeurodegenerative diseaseInfection
05
Safety considerations
Impacts on secretion pathwaysPotential for synthetic lethality when combined with other pathway defects
06
Interacting drugs
Brefeldin A
1 more in the full profile.
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