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BRI3 binding protein (BRI3BP)
- Target
- BRI3BP
- Molecular classification
- Other (not a receptor, enzyme, transporter, ion channel, or transcription factor; typically classified as a binding/adapter or regulatory protein)
01
Overview
BRI3 binding protein (BRI3BP) is an intracellular protein widely expressed in various tissues, most abundantly in the brain, liver, and kidney. It is localized to the endoplasmic reticulum and mitochondria, where it regulates cellular stress responses and is involved in tumorigenesis, potentially by stabilizing the tumor suppressor protein p53 (TP53). BRI3BP is implicated in cancer biology through protein-protein interactions and may serve as a molecular marker for cancer, although it is not a typical drug target like a receptor or enzyme.
- Other names
- KG19HCCRBP-1HCCRBP-3BNAS1HCCR-2I3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding protein
02
Biological functions
Tumorigenesisp53/TP53 stabilizationregulation of cellular stress responses
03
Disease associations
Cancer
04
Biomarkers
p53/TP53 activity (as BRI3BP may stabilize p53 protein)possible association with cancer progression or prognosis
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