Target intelligence / Profile preview

Bridge-like lipid transfer protein family member 3A (BLTP3A)

Target
BLTP3A
Molecular classification
Bridge-like lipid transfer protein (BLTP) family, Lipid transport protein, Tube-forming lipid transport protein, Repeating β-groove (RBG) domain superfamily
01

Overview

BLTP3A is a member of the bridge-like lipid transfer protein (BLTP) family, proteins which form elongated rod-like structures containing internal hydrophobic grooves that can transfer multiple lipid molecules simultaneously between organelles at tight membrane contact sites[2][3][5]. BLTP3A is primarily localized to intracellular organelles, such as the late endosome, and may be involved in retrograde vesicular trafficking and general lipid homeostasis within cells[2]. The BLTP protein family is structurally characterized by repeating β-groove (RBG) domains that assemble into a tube-shaped scaffold spanning membrane interfaces and facilitating non-vesicular lipid exchange[3][5]. BLTP3A does not have established functions as a drug target, receptor, or enzyme, and its roles in human disease, though potentially implicated in rare disorders, are still under investigation[2][3][5].

Other names
C6orf107UHRF1BP1FLJ20302dJ349A12.1ICBP90-binding protein 1SHIP164BUHRF1-binding protein 1Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1
02

Biological functions

Lipid transfer between organelles at membrane contact sitesLipid homeostasis and membrane biogenesisRetrograde traffic within endocytic pathway to Golgi complexProtein binding (histone deacetylase binding, identical protein binding)
03

Disease associations

Barbiturate dependenceHypogonadotropic hypogonadism 14 with or without anosmiaOther roles in organelle membrane lipid composition and possibly neurodevelopmental phenotypes (inferred)

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