Bridging integrator 3 (BIN3)

Bridging integrator 3 (BIN3) is a member of the BAR domain protein family, which bind to cell membranes, regulate actin dynamics, and contribute to processes such as cytokinesis and septation by helping localize F-actin. BIN3 contains a single BAR domain predicted to form coiled-coil structures allowing dimerization, interaction with small GTPases, and sensing or inducing membrane curvature[2][5]. The protein is implicated in endocytosis, membrane trafficking, and other forms of intracellular transport, and plays roles in the regulation of cell shape and division[2][5]. In cancer biology, lower expression of BIN3 correlates with poorer prognosis in several cancers, is associated with altered immune cell infiltration, and may function as a tumor suppressor, particularly in esophageal carcinoma[1]. Beyond oncology, genetic studies have implicated BIN3 in neurodevelopmental disorders, such as autism spectrum disorder[2]. There are currently no approved drugs or direct pharmacological modulators targeting BIN3.

Other names

BIN3Bridging integrator 3BAR domain-containing protein BIN3