BRO1 domain-containing protein BROX (BROX)

BRO1 domain-containing protein BROX (BROX) is an accessory factor in the ESCRT (endosomal sorting complex required for transport) machinery, involved in membrane remodeling, protein sorting, and nuclear envelope reassembly. The protein contains a single Bro1 domain and a C-terminal CAAX motif, which is farnesylated to enable membrane association. BROX binds the ESCRT-III subunit CHMP4, facilitating multivesicular body formation and proper endosomal cargo trafficking, including the regulation of proteins such as EGFR. Mutations in BROX are implicated in familial non-medullary thyroid cancer, highlighting a role in maintaining cellular homeostasis. BROX is upregulated by SGK1.1 and coordinates vesicular traffic with cell survival signaling, but it is dispensable for some ESCRT-associated viral events (e.g., HSV-1 budding). Structurally, BROX forms a curved domain similar to the yeast Bro1 and human ALIX proteins, with distinct features in its C-terminus relevant for membrane association and functional specificity. No drugs or clinical biomarkers are currently associated with BROX, and its status is primarily that of a cellular sorting accessory rather than a direct therapeutic target.

Other names

BROXBRO1 domain and CAAX motif containingBROFTIC1orf58FLJ32421BRO1 domain-containing protein BROXBRO1 domain-containing proteinBRO1 domain- and CAAX motif-containing proteinC1ORF58BROX_HUMAN

Not applicable. BROX is not currently a drug target