Broad set of surface and extracellular proteins on skin and mucosa

The term Broad set of surface and extracellular proteins on skin and mucosa refers to a non-specific collection of proteins rather than a single molecular target. This group includes structural proteins like keratins and collagens, as well as various cell-surface receptors and mucins that maintain the integrity of the body's external and internal barriers (StatPearls, 2023). In pharmacology, this broad set is the primary site of action for topical agents known as astringents and certain antiseptics, such as silver nitrate and aluminum acetate (PubChem, 2024). These drugs work by precipitating or cross-linking proteins on the surface of the skin or mucous membranes, which leads to tissue contraction, reduced exudate, and the formation of a protective physical layer. While this mechanism provides broad-spectrum antimicrobial activity and helps manage minor skin irritations, it lacks the specificity required for modern targeted therapies. Consequently, it is considered an 'incorrect' or overly broad target in the context of precision medicine, though it remains a relevant concept in traditional topical wound care and dermatology (ScienceDirect, 2022).

Other names

Surface proteinsExtracellular matrix proteinsEpithelial surface proteinsMucosal proteins

Non-specific protein precipitation, denaturation, or cross-linking on the tissue surface to create a protective barrier or exert antimicrobial effects.