Broader kinase panel

A broader kinase panel is a comprehensive collection of protein and lipid kinases used in pharmacological screening to assess the selectivity and potency of drug candidates across the human kinome (Manning et al., 2002). These panels typically encompass hundreds of distinct enzymes, including receptor tyrosine kinases, non-receptor tyrosine kinases, and serine/threonine kinases, allowing researchers to identify both intended and unintended molecular interactions (Davis et al., 2011). In the context of drug development, profiling compounds against such a panel is a critical step for predicting potential off-target toxicities and understanding the polypharmacology of multi-kinase inhibitors (Karaman et al., 2008). While not a single therapeutic target itself, the results from these panels guide the optimization of lead compounds to ensure high specificity for the desired disease-related kinase. This systematic approach is essential for the development of targeted therapies in oncology, immunology, and other therapeutic areas where kinase dysregulation plays a central role (Knight et al., 2010).

Other names

Kinome profiling panelKinase selectivity panelMulti-kinase screening panelKinomeScanSelectScreen kinase panel

Inhibition of multiple protein kinases across different families within the kinome