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Target intelligence / Profile preview
Bromodomain and Extra-Terminal Domain (BET) family protein (BET protein)
- Target
- BET protein
- Molecular classification
- Transcription factor, Epigenetic regulator, Bromodomain containing protein
01
Overview
BET family proteins (BRD2, BRD3, BRD4, and BRDT) are epigenetic regulators characterized by two tandem bromodomains and an extra-terminal (ET) domain. The bromodomains bind acetylated lysine residues on histone tails, influencing chromatin structure and gene transcription. The ET domain mediates protein-protein interactions. BET proteins play roles in cell cycle control, development, and are implicated in diseases such as cancer and viral infections, making them therapeutic targets.
- Other names
- Extra-terminal Domain ProteinBRD2BRD3BRD4BRDT
02
Mechanism of action
Inhibition of bromodomain binding to acetylated lysine residues; disruption of ET domain-mediated protein-protein interactions
03
Biological functions
Transcription regulationCell cycle controlMeiosisEmbryonic developmentChromatin organizationEpigenetic regulation
04
Disease associations
CancerViral infections
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