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Target intelligence / Profile preview
Bromodomain and Extra-Terminal Domain Proteins (BET Proteins)
- Target
- BET Proteins
- Molecular classification
- Epigenetic reader protein, Transcription factor
01
Overview
Bromodomain and extra-terminal domain (BET) proteins are a family of epigenetic "reader" proteins that play a central role in the regulation of gene transcription. They are characterized by the presence of two tandem N-terminal bromodomains (BD1 and BD2) and a conserved extra-terminal (ET) domain. BET proteins bind to acetylated lysines on histone tails, thereby regulating chromatin structure and gene expression during cellular proliferation and differentiation. BET family dysfunction is implicated in several diseases, including cancer and viral infection.
- Other names
- Bromodomain-containing proteinsBRDsBET family
02
Mechanism of action
Inhibition of bromodomain-acetyllysine interactions, disrupting BET-mediated gene activation
03
Biological functions
Epigenetic regulationTranscriptional activationChromatin remodelingGene expression regulationProtein-protein interactions
04
Disease associations
CancerViral infectionInflammation
05
Interacting drugs
BET bromodomain inhibitors
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