Bromodomain and WD repeat-containing protein 1 (BRWD1)

Bromodomain and WD repeat-containing protein 1 (BRWD1) is a member of the WD repeat protein family, characterized by multiple WD repeat motifs (each about 40 amino acids, typically facilitating multiprotein complex formation) and two bromodomains[1][3][8]. BRWD1 is thought to function in a range of cellular processes, including cell cycle control, apoptosis, signal transduction, and gene regulation, and may act as a transcriptional activator and chromatin remodeler, especially in the context of regulating cell morphology and the cytoskeleton[3][8]. Mouse homolog studies suggest a role in transcriptional activation associated with chromatin remodeling complexes such as SWI/SNF[3]. In humans, BRWD1 is encoded by the BRWD1 gene on chromosome 21 and is associated with diseases such as primary ciliary dyskinesia and bronchiectasis[3]. Its function in normal physiology and pathology is still under investigation and there are currently no known therapeutic drugs or biomarkers directly targeting BRWD1 as of the latest published resources[1][3][8]. BRWD1 is not currently regarded as a canonical therapeutic target (e.g., receptor, enzyme) and is more accurately categorized as a chromatin-remodeling regulatory protein[1][3][8].

Other names

WD repeat-containing protein 9WDR9C21orf107DCAF19FLJ11315N143WRD9transcriptional unit N143WD repeat protein WDR9-form2CILD51