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Target intelligence / Profile preview
Bromodomain-containing protein 2 (BRD2)
- Target
- BRD2
- Molecular classification
- Transcription factor, Chromatin reader, BET family protein
01
Overview
BRD2 is a nuclear chromatin reader protein belonging to the BET family. It binds to acetylated lysine residues on histone tails, influencing transcription, cell cycle progression, and alternative splicing. It has been implicated in cancer and metabolic disorders, making it a target for BET inhibitors.
- Other names
- D6S113EFSHFSRG1NATRING3RNF3
02
Mechanism of action
BET inhibitors disrupt bromodomain-acetyllysine interactions, preventing BRD2 and other BET proteins from binding to acetylated histones and regulating gene expression.
03
Biological functions
Chromatin bindingTranscription regulationCell cycle controlGrowth controlAlternative splicing
04
Disease associations
CancerMetabolic DisordersObesity
05
Interacting drugs
BET inhibitors
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