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Target intelligence / Profile preview
Bromodomain-containing protein 3 (BRD3)
- Target
- BRD3
- Molecular classification
- Bromodomain and Extra-Terminal motif (BET) family protein, Chromatin reader, Transcription factor, Bromodomain kinase (BRDK) family, Epigenetic regulator
01
Overview
Bromodomain-containing protein 3 (BRD3) is a member of the BET family of proteins and acts as a chromatin reader. It recognizes acetylated lysine residues on histones and transcription factors, regulating gene expression through chromatin remodeling. BRD3 plays roles in erythroid differentiation, gene regulation, and interacts with viral proteins. It is a therapeutic target for anticancer and anti-inflammatory therapies.
- Other names
- ORFXRING3LRING3-like protein
02
Mechanism of action
Inhibition of bromodomain binding to acetylated lysine residues, disrupting protein-protein interactions and affecting gene expression.
03
Biological functions
Chromatin remodelingRegulation of gene expressionRegulation of red cell-specific gene expressionErythroid differentiationTranscription factor complex stabilizationNucleosome remodelingRNA binding
04
Disease associations
CancerNasopharyngeal carcinomaBladder cancer
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