Target intelligence / Profile preview

Bromodomain-containing protein 4 BD2 domain (BRD4-BD2)

Target: BRD4-BD2
Molecular classification: Bromodomain protein, Epigenetic reader, Transcription factor

Overview

The second bromodomain (BD2) of Bromodomain-containing protein 4 (BRD4). It recognizes and binds to acetylated lysine residues on histone tails and non-histone proteins, regulating gene transcription and chromatin structure. It is a target for small molecule inhibitors in cancer and inflammatory diseases.

Mechanism of action

Inhibition of acetyl-lysine binding, leading to altered gene transcription

Biological functions

Transcription regulationChromatin remodelingEpigenetic regulationGene expression regulation

Disease associations

CancerInflammation

Interacting drugs

BET inhibitors

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