Target intelligence / Profile preview

Bromodomain-containing protein 4 binding domain 1 (BRD4 BD1)

Target: BRD4 BD1
Molecular classification: Bromodomain protein, Epigenetic regulator

Overview

Bromodomain-containing protein 4 binding domain 1 (BRD4 BD1) is a bromodomain within the BRD4 protein, a member of the BET family. It functions as an epigenetic "reader" by recognizing and binding to acetylated lysine residues on histones, particularly H4K5AcK8Ac. This interaction plays a key role in transcriptional regulation, cell cycle progression, and chromatin remodeling. BRD4 BD1 is a validated drug target, with inhibitors like JQ1 showing promise in cancer therapy by disrupting oncogenic transcriptional programs.

Mechanism of action

Competitive inhibition of acetyl-lysine binding

Biological functions

Transcriptional regulationChromatin remodelingCell cycle controlEpigenetic regulation

Disease associations

CancerInflammation

Safety considerations

Potential for off-target effects due to structural similarity with other bromodomains

Interacting drugs

JQ1

1 more in the full profile.

Beyond the preview

Go deeper on Bromodomain-containing protein 4 binding domain 1 (BRD4 BD1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Bromodomain-containing protein 4 binding domain 1 (BRD4 BD1).

Explore the full profile