Bromodomain-containing protein 8 (BRD8)

Bromodomain-containing protein 8 (BRD8) is a nuclear protein encoded by the BRD8 gene, characterized by the presence of one or two bromodomains which recognize acetylated lysine residues on histones and transcription factors. BRD8 functions as an accessory subunit of histone acetyltransferase complexes such as NuA4/TIP60, where it regulates chromatin structure, genome stability, and gene expression in concert with other complex members. As a nuclear receptor coactivator, it modulates transcription driven by thyroid hormone, androgen, estrogen, glucocorticoid, progesterone, and retinoid X receptors, among others. BRD8 plays a prominent role in cell cycle progression, DNA repair, and cell proliferation, particularly in cancers where it is frequently overexpressed and promotes resistance to cytotoxic therapies. BRD8 is under investigation as an epigenetic and oncologic therapeutic target due to its pivotal role in chromatin regulation and cancer cell survival[1][2][3][4][5].

Other names

SMAPSMAP2TrCP120p120Skeletal muscle abundant proteinSkeletal muscle abundant protein 2Thyroid hormone receptor coactivating protein of 120 kDathyroid hormone receptor coactivatortrCP120

Small molecule inhibitors of bromodomains block acetyl-lysine recognition and transcriptional coactivation functions\nTargeting BRD8 can suppress cell proliferation and induce cell cycle arrest and apoptosis in cancer models[1][2][4].