Bromodomain-Containing Protein Family (BRD)

The bromodomain-containing protein family comprises proteins that possess at least one bromodomain, a conserved structural motif that specifically recognizes and binds to acetylated lysine residues, primarily on histone tails. Through this recognition, bromodomain-containing proteins act as "readers" of epigenetic marks and play crucial roles in regulating gene expression by facilitating chromatin remodeling and transcriptional activation or repression. They are classified into families like BET and non-BET proteins, with diverse functions in cell proliferation, differentiation, DNA damage repair, and oncogenesis. Different bromodomain subfamilies exhibit distinct histone recognition specificities. The family members are central regulators in epigenetics due to their ability to interpret lysine acetylation signals on histones—a key mechanism underlying dynamic changes in gene expression during development and disease states such as cancer.

Other names

Bromodomain proteinsBRD proteinsBromodomain-containing proteins

Binding to acetylated lysine residues on histones, thereby modulating gene transcription.