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Target intelligence / Profile preview
Bromodomain-containing protein Second Bromodomain (BD2)
- Target
- BD2
- Molecular classification
- Protein Domain, Bromodomain, Epigenetic reader
01
Overview
The second bromodomain (BD2) found in BET family proteins (BRD2, BRD3, BRD4, and BRDT). BD2 is an epigenetic reader that recognizes acetylated lysine residues on histone tails, thereby regulating gene expression. Inhibition of BD2 is being explored as a therapeutic strategy in cancer and inflammatory diseases.
- Other names
- BET Bromodomain 2BRD2 BD2BRD3 BD2BRD4 BD2BRDT BD2
02
Mechanism of action
Inhibition of acetylated lysine binding
03
Biological functions
Histone recognitionTranscription regulationEpigenetic regulation
04
Disease associations
CancerInflammationLeukemiaNUT midline carcinoma
05
Safety considerations
Potential for off-target effectsDose-limiting toxicities (for pan-BET inhibitors)
06
Interacting drugs
XY221/16o
3 more in the full profile.
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