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Target intelligence / Profile preview
Bromodomain-containing protein testis-specific (BRDT)
- Target
- BRDT
- Molecular classification
- Bromodomain and Extra-Terminal motif (BET) protein, Transcription factor, Chromatin remodeling factor
01
Overview
Bromodomain-containing protein testis-specific (BRDT) is a member of the BET (Bromodomain and Extra-Terminal motif) family of proteins. It is a chromatin remodeling factor that plays a crucial role in spermiogenesis and the regulation of gene expression during spermatogenesis. BRDT is expressed specifically in male germ cells and recognizes acetylated histone H4. Inhibition of BRDT is being investigated as a potential target for non-hormonal male contraception.
02
Mechanism of action
Inhibition of BRDT chromatin-binding activity
03
Biological functions
Chromatin remodelingTranscription regulationSpermatogenesisMeiosisGene expression
04
Disease associations
Male infertility
05
Safety considerations
Potential for broader biological effects due to off-target activity against other BET family proteins (BRD2/3/4)
06
Interacting drugs
JQ1
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