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Target intelligence / Profile preview
Bromodomain testis-specific protein (BRDT)
- Target
- BRDT
- Molecular classification
- BET family, Transcription factor, Epigenetic regulator
01
Overview
Bromodomain testis-specific protein (BRDT) is a member of the bromodomain and extra-terminal motif (BET) protein family. It acts as an epigenetic reader by binding acetylated histones, regulating transcriptional activity and chromatin organization during spermatogenesis. BRDT is a potential target for male contraception and cancer therapy due to its role in testis-specific gene expression and aberrant expression in some tumors.
- Other names
- Cancer/testis antigen 9CT9
02
Mechanism of action
BET inhibitors block the region responsible for chromatin binding on BRDT, inhibiting its role in testis-specific gene expression and chromatin reorganization.
03
Biological functions
Epigenetic regulationTranscriptional controlChromatin remodelingRegulation of gene expressionSpermatogenesis
04
Disease associations
Male infertilityCancer
05
Safety considerations
Off-target effects due to BET inhibitors targeting all BET family members.Potential for temporary sterility
06
Interacting drugs
JQ1
1 more in the full profile.
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