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Brown Adipose Tissue Thermogenesis
- Molecular classification
- Metabolic Process, Thermogenesis
01
Overview
Brown adipose tissue (BAT) thermogenesis is a biological process where brown fat generates heat to maintain body temperature. This process, mediated primarily by UCP1, involves uncoupled mitochondrial respiration, leading to energy dissipation as heat. BAT thermogenesis plays a role in energy expenditure, glucose and lipid metabolism, and may influence systemic metabolism through the secretion of batokines. Strategies aimed at activating or increasing functional brown/beige fat are being explored as potential therapies for obesity and metabolic diseases.
- Other names
- BAT ThermogenesisNon-shivering ThermogenesisBrown Fat Metabolism
02
Mechanism of action
β3-Adrenergic receptor agonists stimulate UCP1 expression and activity in brown adipocytes, increasing thermogenesis.
03
Biological functions
ThermogenesisMetabolic RegulationEnergy ExpenditureGlucose MetabolismLipid MetabolismEndocrine Function
04
Disease associations
ObesityType 2 DiabetesMetabolic Syndrome
05
Safety considerations
Off-target effects of β3-Adrenergic receptor agonistsChallenges in translating animal model findings to humansLimited long-term efficacy dataPotential cardiovascular effects
06
Interacting drugs
β3-Adrenergic receptor agonists
07
Biomarkers
UCP1 expression levelsBAT activity (measured by FDG-PET/CT)BAT mass
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