BRWD1 antisense RNA 1 (BRWD1-AS1)

BRWD1 antisense RNA 1 (BRWD1-AS1) is a long non-coding RNA (lncRNA) gene located on chromosome 21, overlapping the BRWD1 locus; it is part of the lncRNA class and functions as an antisense RNA. BRWD1-AS1 is thought to regulate gene expression of its neighboring protein-coding gene BRWD1, likely via mechanisms that involve transcriptional interference, chromatin modification, or modulation of epigenetic states[1][2][3]. The clinical relevance of BRWD1-AS1 is limited, but some genomic studies have associated its locus with autism spectrum disorder[1]. Unlike conventional therapeutic protein targets, BRWD1-AS1 is not targeted by approved drugs nor described as a biomarker or a direct disease modifier. Its molecular role fits within the broader landscape of antisense and non-coding RNAs in gene regulation, where such molecules can act locally (in cis) or, rarely, in trans to affect the expression of adjacent or distant genetic elements[2]. If you need information about the protein-coding gene BRWD1 or its associated protein functions, please clarify, as this entry refers to the non-protein-coding antisense RNA transcript overlapping the BRWD1 locus.

Other names

BRWD1-AS2BRWD1-IT2C21orf87NCRNA00257BRWD1 antisense RNA 2BRWD1 intronic transcript 2 (non-protein coding)