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Target intelligence / Profile preview
BST2 interferon-stimulated positive regulator (BISPR)
- Target
- BISPR
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
BST2 interferon-stimulated positive regulator (BISPR) is a long non-coding RNA (lncRNA) that is induced by interferons and acts as a positive transcriptional regulator of the BST2 (Tetherin) gene, a key interferon-stimulated gene involved in restricting viral particle release from infected cells[1][4]. BISPR is produced from a bidirectional promoter shared with BST2 and is regulated through the JAK–STAT signaling pathway in response to both type I and type II interferons[1][4]. Experimental evidence demonstrates that BISPR expression precedes and enables the induction of BST2 upon interferon stimulation, and knockdown of BISPR decreases BST2 transcript levels specifically without affecting other genes[1]. BISPR is not a protein-coding gene, not a receptor, and is not in itself a direct therapeutic target; it serves instead as a gene regulator lncRNA, critical for proper interferon-mediated upregulation of the antiviral factor BST2[1][4].
- Other names
- lncBST2BST2 IFN-stimulated positive regulatorCTD-2521M24.9BISPR
02
Mechanism of action
Not applicable; no drugs are reported to target this lncRNA directly
03
Biological functions
Regulation of gene expressionPositive regulation of BST2 (Tetherin) gene expressionModulation of interferon (IFN) signaling response
04
Disease associations
InfectionImmune response regulationPotential roles in other antiviral and inflammatory conditions (based on the function of BST2 and IFN pathways)
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